Different dead space indices can provide useful information in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) patients, where changes in microvasculature are the main determinants for the increase in dead space and consequently a worsening of the outcome. Dead space is not routinely measured in critical care practice, because the difficulties in in interpreting capnograms and the different methods of calculations. Policy of Dealing with Allegations of Research MisconductĪbstract: Dead space is the portion of each tidal volume that does not take part in gas exchange and represents a good global index of the efficiency of the lung function.
Policy of Screening for Plagiarism Process.Surfactant depletion had no further influence on the dead space increase during MV, but impaired the reversibility of the dead space increase.ĬO2 sensor Fowler's method mainstream capnography single-breath diagram surfactant depletion. This increase was mostly reversible by switching back to SB. Dead space and wasted ventilation during MV increased with tidal volume. During SB, the dead space volume was 0.21 ± 0.14 ml and increased significantly at MV to 0.39 ± 0.03 ml at a tidal volume of 5 ml/kg and to 0.6 ± 0.08 ml at a tidal volume of 8 and 11 ml/kg. Dead space increase and reversibility of the increase was investigated during MV with different tidal volumes and during SB. Absolute dead space and wasted ventilation (dead space volume in relation to tidal volume) were determined over a period of 1 h. The sensor was used for determination of dead space volume in healthy and surfactant-depleted rats (n = 62) during spontaneous breathing (SB) and mechanical ventilation (MV) at three different tidal volumes: 5, 8, and 11 ml/kg. Therefore, in this study, we developed a new mainstream capnograph designed for the utilization in small animals like rats. Unfortunately, most existing CO2 sensors do not work with the low tidal volumes found in small animals. Hereby, measured carbon dioxide (CO2) in exhaled gas volume is analyzed using the single-breath diagram for CO2.
Volumetric capnography is a standard method to determine pulmonary dead space.
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